Objective: The study aimed to analyze the results of the intratympanic injection of gentamicin as a treatment option for patients with unilateral Ménière`s disease who were refractory to medical treatment. Material and Methods: We present a prospective and longitudinal descriptive study with the results of intratympanic gentamicin in 64 patients labelled of Ménière`s disease in the Otolaryngology Department of Universitary Miguel Servet Hospital in the last years, after a follow-up period of more tan a year, during which controlled medical treatment had been proved unsuccessful. AAO-HNS criteria for reporting treatment results was followed. Results: Complete control of vertigo (class A) was obtained in 65,62% and complete or substantial control of vertigo (class A+B) in 84,37%. 12 patients (18,75%) had a significantly hearing loss.

Conclusions: intratympanic  gentamycin administration using this particular protocol can control vertigo in the majority of patients and is a good option as an alternative treatment to more aggressive techniques in the patients with Ménière`s disease who do not respond to medical treatment.